(26 reviews)
£78.00 GBP
3.90 Points
Single Bottle (45 Servings)
SKU: UK13081

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  • Only product on the market delivering Glucosamine, Pycnogenol®, and Hyaluronic Acid in a Isotonic form.
  • Studies suggest these ingredients may help support and maintain joint health and flexibility. These ingredients include:
    • Glucosamine – A building block of cartilage and joint tissue.
    • Pycnogenol® – Has been shown in studies to support joint comfort.
    • Hyaluronic Acid – Major component of joint synovial and cartilage.
  • Ideal for men and women with an active lifestyle and/or aging.
  • Glucosamine is not readily available from food sources, making supplementation ideal for glucosamine needs.
  • Pycnogenol® is highly bioavailable to the body, making it easily absorbed, according to studies.
  • Hyaluronic Acid may help import joint flexibility and is a major component of joint synovial fluid.
  • Easy-to-take, great tasting, Isotonic formula for anyone who has difficulty swallowing tablets.
  • This gluten free product contains no added wheat, soy, gluten, artificial flavours, salt, preservatives or milk. Offered with the fastest and most efficient delivery system of all nutraceuticals with Isotonix.
  • Produced to high GMP (Good Manufacturing Practises) quality standards.
  • Does not contain MSM or Chondroitin. Chondroitin has poor absorption due to its high molecular weight and has inconclusive research. Research on MSM is also inconclusive, and it take large quantities (2-6 grams) daily for effects to become noticeable.

Product Classifications

Product Classifications

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardised Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

Why Choose Prime Joint by Isotonix?

Why Choose Prime Joint by Isotonix?

As the body ages, many people experience joint discomfort. Market United Kingdom understands how important it is to stay active and happy, so one option is to take a joint supplement to help promote overall bone and joint health. It is critical when choosing a joint supplement to choose one that has the ingredients essential to joint health. Prime Joint Support Formula contains three, some of which aren’t readily available from food sources, making supplementation ideal to obtain the benefits found within them. 

When looking at a joint supplement, there is one main non-controversial ingredient found in most products on the market, glucosamine. The research behind glucosamine is consistent and its benefits effective. Prime Joint Support Formula contains glucosamine, naturally produced by the body and a key component of cartilage. Glucosamine is a component of glycosaminoglycan, a molecule used in the body in the production of cartilage and other body tissues. An aminomonosaccharide (a combination of the amino acid — glutamine and a sugar — glucose), glucosamine is concentrated in joint cartilage and has been scientifically proven to support healthy joint function and promote the normal production of synovial fluid, which lubricates your joints and regenerates cartilage. 

Hyaluronic Acid is a component of synovial fluid and cartilage in joints and is one of the main lubricating components. It is present in every tissue of the body. Although it is produced naturally by the body, the levels of hyaluronic acid diminishes with age, contributing to stiff and painful joints. Prime Joint Support Formula contains 25mg of Hyaluronic Acid to help support and maintain joint health and flexibility.

Contains Pycnogenol® (French maritime pine bark extract) which is the most clinically researched and potent bioflavonoid with more than 120 studies published in peer-reviewed medical journals. For more information visit:

Your body and joints deserve the best, and Isotonix Prime Joint Support Formula is the only product on the market delivering glucosamine, hyaluronic acid, and Pycnogenol® in Isotonic form. Take control of your joint health, and buy Isotonix Joint Support Formula now!

Learn More

Isotonix Delivery System

Isotonix – The World’s Most Advanced Nutraceuticals

Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do to obtain maximum absorption of the nutrients. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and rapidly absorb into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Key Ingredients

Glucosamine (HCl): 1000 mg
Glucosamine is a molecule that is naturally synthesized in the body from glucose and the amino acid glutamine. Glucosamine is an important constituent of glycosaminoglycans in cartilage matrix and synovial fluid. As our bodies age, we are less able to produce glucosamine, resulting in cartilage that is less flexible and weak. Although the mechanism is currently unclear, studies have shown that glucosamine supplementation can support normal, healthy cartilage cell production to help maintain overall joint health.

Pine Bark Extract (Pycnogenol®): 25 mg
Pycnogenol is a water-soluble flavonoid complex with powerful benefits. Pycnogenol, similar to the proanthocyanins found in grape seeds, is extracted from the bark of the French Maritime Pine tree. Numerous studies have examined the anti-inflammatory properties of Pycnogenol. Pycnogenol supplementation can also promote normal COX-2 and 5-LOX gene expression and support healthy leukotriene biosynthesis. In addition, studies have shown the ability of Pycnogenol to cross-link collagen fibers and strengthen connective tissue proteins.

Hyaluronic Acid (Sodium Hyaluronate): 25 mg 
Hyaluronic acid plays an important role in tissue hydration, lubrication and cellular function. Although it is produced naturally by the body, the level of hyaluronic acid diminishes with age, contributing to joint discomfort. It is a key component of cartilage, and is important for skin, joint and eye health. Hyaluronic acid has been shown to help maintain strong, healthy cartilage. It may also enhance synovial fluid production and promote normal healing.

Frequently Asked Questions

What is the recommended dosage?
Pour 2 level, white bottle capfuls of powder into a cup. Add 120 mL of (line on the over cap indicates 60 mL) of water and stir. Maximum absorption occurs when taken on an empty stomach. This product is isotonic only if the specified amounts of powder and water are used.

What is Synovial Fluid and how does it contribute to Joint Health?
Synovial fluid is a thick, stringy fluid found in the cavities of synovial joints. It reduces friction between the articular cartilage and other tissues in joints by lubricating and cushioning them during movement. Synovial Fluid is made of Hyaluronic Acid and lubricin, proteinases, and collagenases. Synovial fluid aids in the nutrition of articular cartilage by acting as a transport medium for nutritional substances, such as glucose, and provides lubrication of the articulating surfaces.

What other products should I take with Prime Joint Support Formula by Isotonix to support my joint health?
Heart Health™ Essential Omega III is a great pair with Prime Joint Support Formula as omega III fatty acids have been shown to support healthy joint lubrication.

How often should I take Prime Joint Support Formula by Isotonix?
This product is most effective when taken daily.

How much Pycnogenol® is in Prime Joint Support Formula by Isotonix?
There are 25 milligrams of Pycnogenol in each daily serving.

Who should not use this product?
If you are currently using warfarin (Coumadin®), other antiplatelet/anticoagulant medications, antihypertensive medications, or have an ongoing medical condition, you should consult your healthcare provider before using this product. If you have a known allergy to shellfish, do not use this product. Women who are pregnant or breastfeeding should not use this product.


  • Belcaro, G., et al. Variations in C-reactive protein, plasma free radicals and fibrinogen values in patients with osteoarthritis treated with Pycnogenol®. Redox Report. 13(6): 271-276, 2008.
  • Blewis, M., et al. A model of synovial fluid lubricant composition in normal and injured joints. European Cells and Materials. 13: 26-39, 2007.
  • Braham, R., et al. The effect of glucosamine supplementation on people experiencing regular knee pain. British Journal of Sports Medicine. 37(1): 45-49, 2003.
  • Canali, R., et al. The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes. International Immunopharmacology. 9(10): 1145-1149, 2009.
  • Chou, M., et al. Effects of chondroitin and glucosamine sulfate in a dietary bar formulation on inflammation, interleukin-1beta, matrix metalloprotease-9, and cartilage damage in arthritis. Experimental Biology and Medicine. 230(4): 255-262, 2005.
  • Cisár, P., et al. Effect of pine bark extract (Pycnogenol®) on symptoms of knee osteoarthritis. Phytotherapy Research. 22: 1087-1092, 2008.
  • Farid, R., et al. Pycnogenol® supplementation reduces pain and stiffness and improves physical function in adults with knee osteoarthritis. Nutrition Research. 27: 692-697, 2007.
  • Gaby, A. Natural treatments for osteoarthritis. Alternative Medicine Review. 4(5): 330-341, 1999.
  • Gouze, J., et al. Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Research and Therapy. 8(6): R173
  • Grimm, T., et al. Inhibition of NF-kappaB activation and MMP-9 secretion by plasma of human volunteers after ingestion of maritime pine bark extract (Pycnogenol®). Journal of Inflammation. 3: 1-15, 2006.
  • Grimm T, Skrabala R, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Durackova Z, Hogger P. Single and multiple dose pharmacokinetics of maritime pine bark extract (Pycnogenol) after oral administration to healthy volunteers. BMC Clinical Pharmacology 2006; 6:4.
  • Hua, J., et al. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. Journal of Leukocyte Biology. 71(4): 632-640, 2002.
  • James, C. and Uhl, T. A review of articular cartilage pathology and the use of glucosamine sulfate. Journal of Athletic Training. 36(4): 413-419, 2001.
  • Laurent, T., et al. Functions of hyaluronan. Annals of the Rheumatic Disease. 54(5): 429-432, 1995.
  • Kelly, G. The role of glucosamine sulfate and chondroitin sulfates in the treatment of degenerative joint disease. Alternative Medicine Review. 3(1): 27-39, 1998.
  • Nakatani, S., et al. Glucosamine regulates differentiation of a chondrogenic cell line, ATDC5. Biological and Pharmaceutical Bulletin. 30(3): 433-438, 2007.
  • Poustie, M., et al. N-butyryl glucosamine increases matrix gene expression by chondrocytes. Journal of Pharmacology and Experimental Therapeutics. 311(2): 610-616, 2004.
  • Reginster, J., et al. Current concepts in the therapeutic management of osteoarthritis with glucosamine. Bulletin (Hospital for Joint Disease). 63(1-2): 31-36, 2005.
  • Reginster, J., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomized, placebo-controlled clinical trial. Lancet. 357(9252): 251-256, 2001.
  • Richy, F., et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of Internal Medicine. 163(13): 1514-1522, 2003.
  • Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol), a herbal medication with a diverse clinical pharmacology. International Journal of Clinical Pharmacology and Therapeutics. 40(4):158-168, 2002.
  • Schäfer, A., et al. Inhibition of COX-1 and COX-2 activity by plasma of human volunteers after ingestion of French maritime pine bark extract (Pycnogenol®). Biomedicine and Pharmacotherapy. 60: 5-9, 2006.

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Displaying reviews  1 - 5 of 26



Shop Consultant
Amazing Product

A MUST HAVE product to any joint sufferers. I've been suffering joints pains to my shoulders and knees. After taking Prime Joint only for few days, the pains began to disappear progressively. All's good since. I am grateful to have been introduced to this amazing product. Go for it and try it, like seriously...you've got nothing to loose. Small investment with happy result! Thank you Isotonix Prime Joint!



Shop Consultant
Best joint pain relief

I have been taking prime joint for about 10 months now with no joint problems.
I didn’t get a new bottle ordered in time and ran out. When it arrived I had been without prime joint for approximately two weeks. I woke one morning and my shoulder pain from a previous injury had returned. I had forgotten what that pain felt like until that moment.
I started back on prime joint and after two days my pain has subsided and I’m getting back to my new normal.
This is such a fantastic product and has helped me so much, I’m so glad I have been introduced to it.


by Anonymous

Great product

I noticed a difference in the way my body felt within 2 days of taking this supplement. Worth it!

Response from Customer Service:

Dear Valued Customer,

Thank you for taking the time to leave your thoughts on the Prime Joint Support Formula by Isotonix®! We are happy to hear you are pleased with the product.

Thank you again!
The Product Information Team


by RexA

Shop Consultant
Staple for my joint care

One of the most important supplements I take. Has really helped with my knee injuries. If you work out or are quite active on a daily basis, this is something you have to add to your repertoire.

Response from Customer Service:

Dear Valued Customer,

Thank you for taking the time to leave your thoughts on the Prime Joint Support Formula by Isotonix! We are happy to hear you are pleased with the product.

Thank you again!
The Product Information Team


by TerryT

Shop Consultant
It works!

Yep, this product really works! All in one formula. I will be buying more.

Response from Customer Service:

Dear Valued Customer,
Thank you for taking the time to leave your thoughts on the Prime Joint support formula. We are happy to hear you are pleased with this product.
Thank you again!
The Product Information Team