Thymenol™

• Provides controlled-multiphase release of ingredients
• Contains ThymoQuin™*, which is 100% pure cold pressed
• ThymoQuin™ is the only blackseed oil standardised to 3% thymoquinone
• The HIGHEST quality blackseed oil on the market
• Black seed products have been used historically in medicine for thousands of years.
• Multi-action antioxidant
• Thymenol™ ingredients may help contribute to cardiovascular and immune health and have been shown to have anti-inflammatory properties.
• Powerful antioxidant that may help protect the body from the effects of free radicals
• Supports cellular health and function
• May help support normal respiratory health
• Numerous scientific studies have shown that the ingredient Pycnogenol may contribute to the maintenance of cardiovascular health, joint health and flexibility, visual health, immune health, blood pressure, antioxidant protection, and blood glucose levels.
• Contains Pycnogenol®* (French maritime pine bark extract) which is one of the most clinically researched and potent bioflavonoids with more than 120 studies published in peer-reviewed medical journals. **
• Pycnogenol is highly bioavailable to the body, making it easily absorbed, according to studies
• Polyphenols and bioflavonoids have been scientifically studied and results indicate that they may contribute to the maintenance of overall good health, due to their antioxidant benefits and their support of healthy circulation.
• This vegetarian product contains no added wheat, soy, yeast, gluten, artificial flavour, colouring, salt, preservatives or milk (lactose)
• Product produced to high GMP (Good Manufacturing Practises) quality standards

*Pycnogenol is a registered trademark of Horphag Research (UK) Ltd. 
*ThymoQuin™ is a trademark of TriNutra Ltd. 
** For more information visit: www.pycnogenol.com

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Vegan - This product is vegan

Quality Standards - GMP Operations and Standardised Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Potency, Purity and Identity

Thymenol™ offers a multi-phase release of ThymoQuin™ and Pycnogenol® via a small prefilled powder cap that is inside of a larger liquid-filled capsule. This blend of ingredients is especially unique as the technology allows the delivery of fat- and water-soluble antioxidants in a single serving. 

ThymoQuin™, is an ingredient standardised to 3% thymoquinone content from black cumin seed, provides unique antioxidant activity. Specifically, ThymoQuin™ limits fat peroxidation, the degradation of lipids where free radicals “steal” electrons from the lipids in cell membranes —helps support cellular health and function. Thymenol™ ingredients may help contribute to cardiovascular and immune health and have been shown to have anti-inflammatory properties. 

Pycnogenol® is a plant extract from the bark of the maritime pine tree, which grows exclusively along the coast of southwest France in Les Landes de Gascogne. Pycnogenol® is a powerful antioxidant and one of the most clinically researched ingredients in the natural health space. 

Along with its potential health benefits, Thymenol™ also offers a clean and sustainable source of its active ingredients. Thymenol™ contains no detectable GMOs or gluten and is vegetarian.

ThymoQuin™ Black Cumin Seed (Nigella sativa) (3% thymoquinone)—500 mg per serving:
ThymoQuin™ is a standardised extract derived from black cumin seed, containing a phytochemical called thymoquinone. Nigella sativa (black cumin seed) is a plant that has been used throughout the world for centuries. Due to its various effects, this plant has a multitude of potential applications. This standardisation of thymoquinone sets this product apart from the competition.

Pycnogenol® Pine Bark Extract – 25 mg per serving:
Published findings have demonstrated Pycnogenol®’s wide array of beneficial effects on the body. Pine bark extract is made of procyanidins, bioflavonoids and organic acids.

Pycnogenol® is a powerful scavenger of free radicals. Numerous scientific studies have shown that the ingredient Pycnogenol may contribute to the maintenance of cardiovascular health, joint health and flexibility, visual health, immune health, blood pressure, antioxidant protection, and blood glucose levels.**

*Pycnogenol is a registered trademark of Horphag Research (UK) Ltd.

*ThymoQuin™ is a trademark of TriNutra Ltd.

** For more information visit: www.pycnogenol.com

Who should use Thymenol™? 
Those that want to boost the benefits of their daily supplement regimen with the powerful ingredients found in Thymenol™ (Black Cumin Seed Oil and French Maritime Pine Bark Extract).

Should I still take Isotonix OPC-3® if I take Thymenol™? 
Yes. The benefits of the five different antioxidants in OPC-3 make it the perfect complimentary supplement to Thymenol™. 

What is the best time of day to use Thymenol™? 
Take two capsules daily with or without food, anytime of day. 

Why is ThymoQuin™ superior over other black cumin seed oils? 
ThymoQuin™, cold-pressed for better preservation of the whole composition of the seed without the use of solvent, is the first and only standardised black cumin seed oil on the market. When you use a standardised ingredient, you get consistent health benefits and a consistent finished product. 

Why was ThymoQuin™ paired with Pycnogenol®? 
ThymoQuin™ by itself has many health benefits, but the real power of ThymoQuin™ is in combination with other ingredients. Studies show that ThymoQuin™ supports and compliments anti-inflammatory potential of other ingredients in a formulation; therefore, the healthy impact of this combination product is more than the ingredients taken separately. 

• Ahmad A, Husain A, Mujeeb M, et al. A review on therapeutic potential of Nigella sativa: A miracle herb. Asian Pac J Trop Biomed. 2013;3(5):337–352.
• Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clin Pharmacol. 2008 Aug; 22(4):447-52.
• Bag, A., & Chattopadhyay, R. R. (2015). Evaluation of synergistic antibacterial and antioxidant efficacy of essential oils of spices and herbs in combination. PloS one, 10(7), e0131321.
• Fallah Huseini H, Amini M, Mohtashami R, Ghamarchehre ME, Sadeqhi Z, Kianbakht S, Fallah Huseini A. Blood pressure lowering effect of Nigella sativa L. seed oil in healthy volunteers: a randomized, double-blind, placebo-controlled clinical trial. Phytother Res. 2013 Dec; 27(12):1849-53.
• Choi YH, Yan GH. Pycnogenol® inhibits immunoglobulin E-mediated allergic response in mast cells. Phytother Res 23: 1691-1695, 2009.
• Datau EA, Wardhana, Surachmanto EE, Pandelaki K, Langi JA, Fias. Efficacy of Nigella sativa on serum free testosterone and metabolic disturbances in central obese male. Acta Med Indones. Jul;42(3):130-4, 2010.
• Gheita TA, Kenawy SA. Effectiveness of Nigella sativa oil in the management of rheumatoid arthritis patients: a placebo controlled study. Phytother Res. 2012 Aug; 26(8):1246-8.
• Mohtashami R, Huseini HF, Heydari M, Amini M, Sadeqhi Z, Ghaznavi H, Mehrzadi S. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol. 2015 Dec 4; 175():147-52.
• Farhangi MA, Dehghan P, Tajmiri S, Abbasi MM. The effects of Nigella sativa on thyroid function, serum Vascular Endothelial Growth Factor (VEGF) - 1, Nesfatin-1 and anthropometric features in patients with Hashimoto's thyroiditis: a randomized controlled trial. BMC Complement Altern Med. 2016 Nov 16;16(1):471.
• Farzaneh E1, Nia FR2, Mehrtash M2, Mirmoeini FS3, Jalilvand M1.; “The Effects of 8-week Nigella sativa Supplementation and Aerobic Training on Lipid Profile and VO2 max in Sedentary Overweight Females,” Int J Prev Med., 2014 February, PMID: 24627749
• Fine, AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev 5:144-51, 2000. Review.
• Fitzpatrick, D., et al. Endothelium-dependent vascular effects of Pycnogenol®. Journal of Cardiovascular Pharmacology 32: 509-515, 1998.
• Golshan Iranpour F, Fazelian K, Dashti GR. Thymoquinone as a natural spermostatic substance in reproductive medicine: An experimental study. Int J Reprod Biomed (Yazd). 2017 Oct;15(10):641-648.
• Gulati, O. Pycnogenol® in venous disorders: a review. European Bulletin of Drug Research 7: 1-13, 1999.
• Nikakhlagh S, Rahim F, Aryani FH, Syahpoush A, Brougerdnya MG, Saki N Herbal treatment of allergic rhinitis: the use of Nigella sativa. Am J Otolaryngol 2011; 32(5):402-7.
• Hosseini, S., et al. Pycnogenol® in the management of asthma. Journal of Medicinal Food 4: 201-209, 2001.
• Kolahdooz M, Nasri S, Modarres SZ, Kianbakht S, Huseini HF.Effects of Nigella sativa L. seed oil on abnormal semen quality in infertile men: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2014 May 15;21(6):901-5. doi: 10.1016/j.phymed.2014.02.006.
• Lau B et al. Pycnogenol® as an adjunct in the management of childhood asthma. J Asthma. 41(8):825-32, 2004.
• Lei, X., Liu, M., Yang, Z. et al. Dig Dis Sci (2012) 57: 2296. https://doi.org/10.1007/s10620-012-2156-x
• Maffei A, Charrier C, Caiati MD, et al. Emerging Mechanisms Underlying Dynamics of GABAergic Synapses. J Neurosci. 2017;37(45):10792–10799. doi:10.1523/JNEUROSCI.1824-17.2017
• Masood Sadiq Butt & Muhammad Tauseef Sultan (2010) Nigella sativa: Reduces the Risk of Various Maladies, Critical Reviews in Food Science and Nutrition, 50:7,654-665, DOI: 10.1080/10408390902768797 Planta Med. 2016 Jan;82(1-2):8-16.
• Packer, L., et al. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritima) bark, Pycnogenol®®. Free Radic Biol Med 27:704-24, 1999. Review.
• Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6(b):495–510.
• Randhawa, Mohammad & Al-Ghamdi, Mastour. (2011). Anticancer Activity of Nigella sativa (Black Seed) - A Review. The American journal of Chinese medicine. 39. 1075-91. 10.1142/S0192415X1100941X.
• Rohdewald, P. A review of the French maritime pine bark extract (Pycnogenol®), a herbal medication with a diverse clinical pharmacology. Int J Clin Pharmacol Ther 40:158-68, 2002. Review.
• Salem ML.; “Immunomodulatory and therapeutic properties of the Nigella sativa L. seed,” Int Immunopharmacol. 2005 Dec, PMID: 16275613.
• Sayeed MSB, Asaduzzaman M, Morshed H, et al. The effect of Nigella sativa Linn seed on memory, attention and cognition in healthy human volunteers. J Ethnopharmacol. 2013;148(3):780–786
• Sharma SC, Sharma S, Gulati OP. Pycnogenol® inhibits the release of histamine from mast cells. Phytother Res, 17: 66-69, 2003.
• Tavakkoli A, Mahdian V, Razavi BM, Hosseinzadeh H. Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone. J Pharmacopuncture. 2017;20(3):179–193. doi:10.3831/KPI.2017.20.021
• Tavakkoli A, Mahdian V, Razavi BM, Hosseinzadeh H. Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone. J Pharmacopuncture. 2017;20(3):179–193.
• Vanamala J1, Kester AC, Heuberger AL, Reddivari L.; “Mitigation of obesity-promoted diseases by Nigella sativa and thymoquinone,” Plant Foods Hum Nutr. 2012 Jun, PMID: 22477645
• Wang ZJ, Heinbockel T. Essential Oils and Their Constituents Targeting the GABAergic System and Sodium Channels as Treatment of Neurological Diseases. Molecules. 2018;23(5):1061. Published 2018 May 2. doi:10.3390/molecules23051061
• Watson, R. Pycnogenol® and cardiovascular health. Evidence-Based Integrative Medicine 1: 27-32, 2003.
• Wilson D et al. A randomized, double-blind, placebo-controlled exploratory study to evaluate the potential of Pycnogenol® for improving allergic rhinitis symptoms. Phytother Res. 24(8):1115-9, 2010.